MBBS Regulations

Pharmacology

3)SYLLABUS  OF  PHARMACOLOGY :

a)      THEORY

SI.No.            Name of  the  Unit                          No.of Hrs.

1.            General pharmacology                                                10

2.            Autonomic  nervous system                                    8

3.            Central  nervous system                                                16

4.            Cardio  vascular  system                                                8

5.            Biogenic amines &  Autocoids                                    3

6.            Respiratory  system                                                2

7.            Blood  and  blood  forming agents anticoagulatns,

            fibrinolytic  drugs  etc.,                                                4

8.            Kidney – diuretics                                                            2

9.            Gastro  intestinal  system                                                3

10.            Drugs  acting on  the  Uterus                                    1

11.             Chemoptherapy                                                            22

12.            endocrinology                                                            10

13.            Dermatological  Pharmacology                                    1

14.            Geriatric  Pharmacology                                                1

15.            Paediatric  Pharamacology/Neonatal

                                                                                                Pharmacology                                                                        1

                        16.                        Safety  of  drugs in  Pregnancy                                                       1

                        17.            Hazards  of smoking, alcohol, narcotics,  enviormental  pollution                                                                        2

                        18.            Immuno Pharamacology                                                1

                        19.            Metalic  poisoning                                                            1

                        20.            Vitamins & Sex  Hormones                                    1

21.              National  Programmes  including  management

Of  AIDS                                                                        2

Total  Hours                                                                        100

                        NOTE: The detailed  syllabus  is vide Annexure(a)

ANNEXURE (a)

                                                DETAILED  SYLLABUS  OF  PHARMACOLOGY

1)                  General  Pharmacology

-  Sources  of  drungs

-  Routes of  drung administration

-  Drug  absorption

-  Drug distribution 

-  Drug   Biotransformation

-  Drug  excretion

-  Methods of prologning  drug action

-  Mechanisms  of  drug action

-  Factors modifying  drug  action

-                     Bio-availability,  Biological  half-life , Bioequivalence,

- Adverse  drug reactions

-Drug dependence

-  Drug  interactions

-  Structural  activity  relationship

-  Clinical  evaluation  of  a  New  drug.

                        2)            Autonomic Nervous System

                                                -   Introduction  to Automic Nervous  system

                                                -  Adrenergic  transmission

                                                -  Adrenergic  drugs

                                                -   Adrenergic  blocking  agents

                                                -   Cholinergic   transmisson

                                                -   Cholionergic  drugs

                                                -   Cholionergic  blocking  agents

                                                -   Anticholinesterases

                                                -   Treatment  of parkinsoism

                                                -   Treatment  of  Organophosphorous poisoining,

                        3)             Central   nervous  system

                                                -    Introduction of historical  aspects,  alcohols          

-   General  Anaesthetics,   basal anaesthesia of          Premedication              

            -    Depressants  - Barbiturates,

                                     Opioids, Benzodiazepines.

                                    Amtipyretics and  analogesis (NSAIDS)

                                                -     Stimulants  -  Central  nervous  system stimulants

                                                      and   spinal  stimulatns.

                        Epilepsy and anticonvulsants

                                                - Drugs  addition

                                                -  Skeletal Muscle  relaxants

                                                -  Local   Anaesthetics

                                                -  Phychopharmacology

                        4) Cardio  Vascular system

                                                -  Cardiac  glycosides

                                                -   anti  arrhthtmic  agents

                                                -  Anti  hypertensives

                                                -  Anti anginal  drugs

-                     Pharmacology of  shock,  Vasodilators  and management of  myocardial infarction,  Cardiogenic shock

-                     Plasma lipid lowering  agents

-                     Diuretics

2)                     Autacoids

-                     Histamine,  Antihistamines

-                     Serotonin  & its  antagonists

-                     Prostaglandins,  Brady Kinins

-                     Polypeptides, Renin-Angiotensin  mechanism

                       6)  Miscellaneous  topics

                                                                                                -                         Heavy   metal  poinsoning

-                     Environmental  poisoning

-                     Hazards  of   smoking

-                     Drugs  of  addtion

-                     Geriatric Pharmacology

-                     Paediatric Pharmacology

-                     Dermatological;  Pharmacology

-                     General  Principles of  management of Poisoning

-                     Drugs  during  pregnancy,  Lactation

-                     Drugs  and preventive measures  for AIDS, and National World  Health Organisation  programmes.

                          7) Chemotherapy

-                     Introduction  and  principles of Antimicrobal  Therapy.

-                     Sulfonamides,  Cotrimoxazole  and  Fluoquinolones

-                     Princillins  and   Newer pencicillans.

-                     Cephalosorings

-                     Macrolides and  other antibiotics

-                     Aminoglycosides antibiotics

-                     Broad  spectrum  antibiotics

-                     Chemotherapy of  UTI

-                     Amtituberculosis  drugs

-                     Anti  Leoprotic  drugs

-                     Antri  Fungal  drums

-                     Anti    viral  drugs  &  chemotherapy of  AIDS

-                     Anti   Malarials

-                        Antiamoebic   drugs

-                     Chemotherapy of other anti  protozal  infections

-                     Anthelminthics

-                     Antisptics,  Disinfectures  and ectoparaites

-                      Chemotherapy  of neoplastic diseases.

                        8) Drugs  acting on  Uterus, Respiratory  System  and G.I.T.

                                                & Blood.

-                     A ppetite stimulants  &  suppressants

-                     Emetis & Anti emetics (prokinetic agents )

-                     Anti diarrahoeal  agents  & Treatment of  diarrhoea

-                     Treatment of peptic ulcer

-                     Purgatives

                        9) Blood

-                     Metalobastic anaemias

-                     Microcytic (iron  deficiency) Anaemiass

-                     Anti  coagulants

-                     Fibrinolytic  agents  & Anti platelet agents

                        10)Drugs  acting on uterus

-                     Uterine stimulants

-                     Uterine  relaxants

                        11)Respiratory  system

                        -            Cough suporessants & Mucolytic agents

-                     Treatment  of  Bronchial Asthma

                                    12)Hormones( Endocrinology)

-                     Posterior piotuitary hormones  & related  factors. ADH.,

-                     Anterior pituitary  growth  hormones

-                     Thyroid  hormone  & Antithyroid  drugs

-                     Diabetes mellitus , oral antidiabetic drugs  and  newer antidiabetic  drugs.

-                     Adrenal cortical steriods  -  Mineral  corticoids  and

Synthetic steroids

-                     parathyroid  -  Parathormone – Clcitonin -  Calcium metabolism

-                     Sex  hormones – Estrogens, Progestins  and anti estrogens, antiprogestins

-                     Androgens -  Antiandrogens

                        ii) Practical  Syllabus (Pharmacology)

                        This  includes  prepation of different  dosage forms,  formulations, prescription writing,clionical  pharmacy exercises, problem based  clinical  study of  cases , drug  interactions , adverse drug  reactions, demonstrations  of  the museum  spciemens  attached to  the department , visit  to  apharamaceutical company, bedside  teaching .

                        iii) Experimental Pharmacology  demonstration

Effects  of  Choilinergic, adrenergic, histaminergic  drugs and their antagonists on dogs.

Skeletal muscfle relaxant effect in rabbits

Opioid analgesic efect,straub’s test inmice

Co vulsant and anticonvulsant effedt of certain drugs in fromgs

General anaesthetic effeft of either in experimental animals using anaesthesis box.

Analgestic and antinflammatory effects of certain drugs in rats and mice by different methods.

Prothromben time estimatioon

Respirato function tests and the effect of drugs I  their alteration- Beta Blockers – selctive and non-selective

General principles of spectroscopyu, colorimetry, Flurimettry, HPLC etc, with live demonstratuion if possible

Clinical pharmaco kinetics :

Study of half  life of a drug, bio-availability etc., wherever facilities are available in tehg acollege or locally at anyt other institute.

1.                  Clinical oriented problems:

            Problem based learining (PBL)

            Continuing Medical Education (CME)

            Integrated teaching (ITC) classes

            Semiars

            Visit to pharamaceutical firms

IV.              SUGGESTED STANDARD TEXT BOOKS

1.                  Pharmacology & Pharamacotherapeutics By Dr. Satoskar

2.                  Esentials of Medical Pharmocology by Dr. Tripathi.

REFERENCE BOOKS :

1.                  Applied & Clinical Pharamacology by Rang Dale & Katazung

2.                  Pharmacological basis of Therapeutics by Goodman & Gillman

3.                  Clinical phracology by laurance.

4.                  Illustrated book inpharmacology by Lippincott.

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